规格

价格

库存

数量

2 mg

¥ 482

5日内发货

5 mg

¥ 798

5日内发货

10 mg

¥ 1,590

5日内发货

100 mg

¥ 6,990

6-8周

1 mL x 10 mM (in DMSO)

¥ 888

5日内发货

生物活性

产品描述	Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase.
体外活性	Tubulin inhibitor 1 is an inhibitor of tubulin.Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells(IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively). Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells.
体内活性	In Balb/c nude mice bearing SK-OV-3 cells, Tubulin inhibitor 1 (50 mg/kg, i.p., )treatment every two days three times for 20-25 days is well tolerated, significantly reduces tumour growth .

化学信息

分子量	368.43
分子式	C₂₁H₂₄N₂O₄
CAS No.	2237054-53-2
Smiles	CCOc1ccc(cc1)-c1cn(C)nc1-c1cc(OC)c(OC)c(OC)c1
密度	1.14 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 125 mg/mL (339.28 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.96 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7142 mL	13.5711 mL	27.1422 mL	135.7110 mL
5 mM	0.5428 mL	2.7142 mL	5.4284 mL	27.1422 mL
10 mM	0.2714 mL	1.3571 mL	2.7142 mL	13.5711 mL
20 mM	0.1357 mL	0.6786 mL	1.3571 mL	6.7855 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	2.7142 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	1.3571 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Tubulin inhibitor 1

Tubulin inhibitor 1

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Tubulin inhibitor 1

Tubulin inhibitor 1